| RUSHING | ATT | YDS | YPC | TD | LG | RUSHING | ATT | YDS | YPC | TD | LG | ||
| Larry Csonka | MIA | 280 | 1344 | 4.8 | 1 | 53 | Ron A. Johnson | NYG | 348 | 1766 | 5.1 | 10 | 67 |
| Floyd Little | DEN | 260 | 1206 | 4.6 | 9 | 48 | MacArthur Lane | STL | 312 | 1524 | 4.9 | 9 | 75 |
| Ed Podolak | KCA | 192 | 1064 | 5.5 | 8 | 65 | Larry Brown | WAS | 315 | 1489 | 4.7 | 10 | 67 |
| Jess Phillips | CIN | 243 | 997 | 4.1 | 9 | 65 | Donny Anderson | GBN | 342 | 1370 | 4.0 | 5 | 34 |
| Emerson Boozer | NYJ | 232 | 926 | 4.0 | 3 | 27 | Calvin Hill | DAL | 223 | 1145 | 5.1 | 6 | 20 |
| Joe Dawkins | HOU | 217 | 903 | 4.2 | 5 | 32 | Cyril Pinder | PHI | 230 | 980 | 4.3 | 5 | 34 |
| Charlie H. Smith | OAK | 188 | 892 | 4.7 | 6 | 24 | Ken Willard | SFN | 257 | 972 | 3.8 | 12 | 20 |
| Leroy Kelly | CLE | 238 | 857 | 3.6 | 3 | 34 | Mel Farr | DET | 193 | 896 | 4.6 | 2 | 36 |
| Jim Nance | BOS | 183 | 758 | 4.1 | 3 | 21 | Les Josephson | LAN | 173 | 861 | 5.0 | 5 | 23 |
| Norm Bulaich | BAL | 165 | 752 | 4.6 | 5 | 15 | Altie Taylor | DET | 196 | 762 | 3.9 | 1 | 34 |
| Frenchy Fuqua | PIT | 182 | 730 | 4.0 | 8 | 33 | Dave Osborn | MIN | 178 | 759 | 4.3 | 3 | 16 |
| O.J. Simpson | BUF | 164 | 728 | 4.4 | 3 | 50 | Tony Baker | NON | 166 | 667 | 4.0 | 3 | 20 |
| Jim Kiick | MIA | 197 | 675 | 3.4 | 3 | 18 | Doug Cunningham | SFN | 151 | 574 | 3.8 | 5 | 22 |
| Paul Robinson | CIN | 134 | 626 | 4.7 | 4 | 20 | Willie Ellison | LAN | 110 | 484 | 4.4 | 0 | 24 |
| Bo Scott | CLE | 142 | 570 | 4.0 | 7 | 18 | Harmon Wages | ATL | 118 | 472 | 4.0 | 4 | 20 |
| Mike W. Richardson | HOU | 135 | 562 | 4.2 | 4 | 34 | Bill Brown | MIN | 121 | 457 | 3.8 | 2 | 18 |
| Preston Pearson | PIT | 142 | 518 | 3.6 | 0 | 28 | Clint Jones | MIN | 117 | 450 | 3.8 | 4 | 20 |
| Wendell Hayes | KCA | 118 | 470 | 4.0 | 1 | 22 | Walt Garrison | DAL | 93 | 445 | 4.8 | 4 | 18 |
| Carl Garrett | BOS | 115 | 448 | 3.9 | 1 | 26 | Charley Harraway | WAS | 81 | 379 | 4.7 | 3 | 57 |
| George Nock | NYJ | 113 | 438 | 3.9 | 2 | 19 | Lee Bouggess | PHI | 105 | 368 | 3.5 | 2 | 20 |
| Hewritt Dixon | OAK | 94 | 415 | 4.4 | 2 | 39 | Cid Edwards | STL | 88 | 367 | 4.2 | 1 | 22 |
| Jeff Queen | SDA | 101 | 362 | 3.6 | 2 | 19 | Cannonball Butler | ATL | 130 | 351 | 2.7 | 2 | 18 |
| Marv Hubbard | OAK | 93 | 361 | 3.9 | 6 | 15 | Jim Otis | NON | 82 | 334 | 4.1 | 2 | 15 |
| Matt Snell | NYJ | 83 | 340 | 4.1 | 1 | 18 | Tucker Frederickson | NYG | 83 | 330 | 4.0 | 3 | 15 |
| Bobby Anderson | DEN | 69 | 332 | 4.8 | 2 | 18 | Don Shy | CHI | 108 | 299 | 2.8 | 4 | 19 |
| Tom Nowatzke | BAL | 89 | 317 | 3.6 | 1 | 14 | Larry L. Smith | LAN | 71 | 272 | 3.8 | 3 | 19 |
| Dickie Post | SDA | 78 | 300 | 3.8 | 2 | 18 | Ross Montgomery | CHI | 57 | 242 | 4.2 | 0 | 16 |
| Essex Johnson | CIN | 44 | 285 | 6.5 | 0 | 26 | Paul Gipson | ATL | 75 | 240 | 3.2 | 3 | 15 |
| Mike Garrett | SDA | 74 | 284 | 3.8 | 1 | 22 | Greg Landry | DET | 46 | 234 | 5.1 | 5 | 39 |
| Warren McVea | KCA | 66 | 278 | 4.2 | 1 | 34 | Johnny Roland | STL | 67 | 232 | 3.5 | 5 | 15 |
| Terry Bradshaw | PIT | 49 | 270 | 5.5 | 1 | 20 | Tom Barrington | NON | 57 | 216 | 3.8 | 1 | 16 |
| Mercury Morris | MIA | 57 | 232 | 4.1 | 3 | 35 | Fran Tarkenton | NYG | 55 | 188 | 3.4 | 3 | 20 |
| Robert 'Tank' Holmes | KCA | 70 | 224 | 3.2 | 3 | 15 | Duane Thomas | DAL | 53 | 185 | 3.5 | 3 | 16 |
| Wayne Patrick | BUF | 60 | 220 | 3.7 | 1 | 20 | Tom Woodeshick | PHI | 64 | 144 | 2.3 | 4 | 17 |
| Virgil Carter | CIN | 47 | 196 | 4.2 | 3 | 43 | Tommy Mason | LAN | 34 | 118 | 3.5 | 0 | 13 |
| Brad Hubbert | SDA | 56 | 186 | 3.3 | 1 | 11 | Jim Grabowski | GBN | 32 | 97 | 3.0 | 0 | 8 |
| Willis Crenshaw | DEN | 64 | 178 | 2.8 | 1 | 25 | Ronnie Bull | CHI | 27 | 81 | 3.0 | 1 | 28 |
| Dennis Shaw | BUF | 42 | 172 | 4.1 | 3 | 19 | Roman Gabriel | LAN | 36 | 81 | 2.3 | 0 | 12 |
| Jack Maitland | BAL | 55 | 138 | 2.5 | 1 | 15 | Bart Starr | GBN | 42 | 75 | 1.8 | 1 | 13 |
| Russ Smith | SDA | 39 | 133 | 3.4 | 0 | 11 | Bobby Duhon | NYG | 16 | 75 | 4.7 | 0 | 15 |
| Sam Havrilak | BAL | 40 | 131 | 3.3 | 0 | 15 | Oscar Reed | MIN | 27 | 66 | 2.4 | 0 | 15 |
| Jerry Hill | BAL | 40 | 127 | 3.2 | 1 | 15 | Dick Davis | NON | 22 | 65 | 3.0 | 0 | 17 |
| Warren Bankston | PIT | 35 | 112 | 3.2 | 2 | 14 | Sonny Campbell | ATL | 18 | 59 | 3.3 | 0 | 7 |
| Al Woodall | NYJ | 27 | 110 | 4.1 | 0 | 21 | Art Malone | ATL | 15 | 56 | 3.7 | 0 | 12 |
| Bill Enyart | BUF | 29 | 108 | 3.7 | 2 | 16 | Jack Concannon | CHI | 11 | 55 | 5.0 | 1 | 16 |
| Joe Kapp | BOS | 19 | 81 | 4.3 | 1 | 14 | Henry Dyer | WAS | 7 | 41 | 5.9 | 3 | 12 |
| Greg M. Jones | BUF | 15 | 77 | 5.1 | 0 | 17 | Joe Morrison | NYG | 8 | 40 | 5.0 | 0 | 17 |
| Gene Foster | SDA | 21 | 69 | 3.3 | 0 | 15 | Mike Hull | CHI | 8 | 36 | 4.5 | 1 | 13 |
| Odell Lawson | BOS | 17 | 67 | 3.9 | 0 | 15 | Lance Rentzel | DAL | 1 | 35 | 35.0 | 0 | 35 |
| John Hadl | SDA | 17 | 53 | 3.1 | 0 | 13 | Elijah Pitts | NON | 12 | 30 | 2.5 | 0 | 7 |
| Lee White | NYJ | 15 | 53 | 3.5 | 0 | 13 | Norm Snead | PHI | 11 | 28 | 2.5 | 0 | 9 |
| Reece Morrison | CLE | 14 | 44 | 3.1 | 0 | 15 | Bob Berry | ATL | 15 | 28 | 1.9 | 2 | 6 |
| Pete Banaszak | OAK | 8 | 36 | 4.5 | 0 | 16 | John Brodie | SFN | 46 | 27 | 0.6 | 2 | 6 |
| Clem Turner | DEN | 12 | 33 | 2.8 | 0 | 12 | Pat Curran | LAN | 9 | 26 | 2.9 | 0 | 7 |
| Pete Liske | DEN | 19 | 33 | 1.7 | 1 | 7 | Roger Staubach | DAL | 10 | 24 | 2.4 | 1 | 9 |
| Bill Nelsen | CLE | 37 | 32 | 0.9 | 2 | 5 | Don McCall | NON | 15 | 20 | 1.3 | 1 | 6 |
| Len Dawson | KCA | 16 | 21 | 1.3 | 1 | 7 | Billy Kilmer | NON | 7 | 20 | 2.9 | 0 | 10 |
| Dick Hoak | PIT | 12 | 19 | 1.6 | 0 | 5 | Jeff L. Jordan | LAN | 5 | 17 | 3.4 | 3 | 8 |
| Fran Lynch | DEN | 6 | 18 | 3.0 | 0 | 6 | Dan Reeves | DAL | 6 | 16 | 2.7 | 1 | 6 |
| Lloyd Pate | BUF | 8 | 18 | 2.3 | 0 | 9 | Charley Taylor | WAS | 1 | 15 | 15.0 | 0 | 15 |
| Bob Griese | MIA | 26 | 16 | 0.6 | 2 | 12 | Gale Sayers | CHI | 5 | 14 | 2.8 | 0 | 7 |
| Jerry Rhome | HOU | 3 | 16 | 5.3 | 0 | 9 | Rick Arrington | PHI | 5 | 14 | 2.8 | 0 | 7 |
| Don Maynard | NYJ | 1 | 12 | 12.0 | 0 | 12 | Walter Roberts | WAS | 6 | 14 | 2.3 | 0 | 13 |
| Daryle Lamonica | OAK | 13 | 11 | 0.8 | 0 | 7 | Sonny Jurgensen | WAS | 20 | 12 | 0.6 | 1 | 14 |
| Alan Pastrana | DEN | 3 | 9 | 3.0 | 0 | 10 | Claxton Welch | DAL | 2 | 10 | 5.0 | 0 | 5 |
| Marty Domres | SDA | 9 | 8 | 0.9 | 0 | 5 | Jim Lindsey | MIN | 2 | 8 | 4.0 | 0 | 9 |
| Steve Tensi | DEN | 2 | 5 | 2.5 | 0 | 3 | Jim Hart | STL | 32 | 7 | 0.2 | 2 | 5 |
| Mike Livingston | KCA | 3 | 5 | 1.7 | 0 | 6 | Craig Baynham | CHI | 5 | 5 | 1.0 | 0 | 4 |
| Sid Blanks | BOS | 2 | 2 | 1.0 | 0 | 2 | Bill Triplett | DET | 3 | 5 | 1.7 | 0 | 4 |
| Roy Hopkins | HOU | 3 | 1 | 0.3 | 0 | 2 | Gary Cuozzo | MIN | 21 | 5 | 0.2 | 0 | 10 |
| Larry Todd | OAK | 2 | 1 | 0.5 | 0 | 1 | Craig Morton | DAL | 18 | 3 | 0.2 | 0 | 5 |
| Earl Morrall | BAL | 1 | 1 | 1.0 | 0 | 1 | Bob Lee | MIN | 7 | 2 | 0.3 | 0 | 8 |
| Dennis Partee | SDA | 1 | 0 | 0.0 | 0 | 0 | Bob Brunet | WAS | 1 | 0 | 0.0 | 0 | 0 |
| Charlie Joiner | HOU | 1 | 0 | 0.0 | 0 | 0 | Steve Owens | DET | 2 | 0 | 0.0 | 1 | 1 |
| Jerry LeVias | HOU | 1 | -1 | -1.0 | 0 | -1 | Bill Munson | DET | 4 | -2 | -0.5 | 0 | 1 |
| Doug Dressler | CIN | 1 | -1 | -1.0 | 0 | -1 | Larry Walton | DET | 1 | -3 | -3.0 | 0 | -3 |
| Mike Taliaferro | BOS | 1 | -1 | -1.0 | 0 | -1 | Bobby Douglass | CHI | 4 | -4 | -1.0 | 0 | -1 |
| Terry Hanratty | PIT | 1 | -1 | -1.0 | 0 | -1 | Dick Shiner | NYG | 9 | -4 | -0.4 | 0 | 1 |
| Joe Namath | NYJ | 3 | -3 | -1.0 | 0 | -1 | Edd Hargett | NON | 4 | -4 | -1.0 | 0 | -1 |
| Charley Johnson | HOU | 6 | -4 | -0.7 | 0 | 1 | |||||||
| Gary Garrison | SDA | 1 | -5 | -5.0 | 0 | -5 | |||||||
| Sam Wyche | CIN | 6 | -6 | -1.0 | 0 | -1 | |||||||
| Johnny Unitas | BAL | 13 | -7 | -0.5 | 0 | 5 |