| RUSHING | ATT | YDS | YPC | TD | LG | RUSHING | ATT | YDS | YPC | TD | LG | ||
| Arian Foster | HOU | 382 | 2418 | 6.3 | 19 | 80 | Steven Jackson | STL | 368 | 2001 | 5.4 | 16 | 42 |
| Chris D. Johnson | TEN | 322 | 1998 | 6.2 | 13 | 71 | Adrian L. Peterson | MIN | 362 | 1843 | 5.1 | 15 | 63 |
| Peyton Hillis | CLE | 356 | 1784 | 5.0 | 9 | 42 | Michael Turner | ATL | 328 | 1825 | 5.6 | 9 | 55 |
| Rashard Mendenhall | PIT | 315 | 1677 | 5.3 | 10 | 65 | Jonathan Stewart | CAR | 260 | 1452 | 5.6 | 6 | 48 |
| Jamaal Charles | KCA | 264 | 1669 | 6.3 | 11 | 47 | Matt Forte' | CHI | 301 | 1447 | 4.8 | 13 | 61 |
| Knowshon Moreno | DEN | 349 | 1636 | 4.7 | 3 | 35 | LeGarrette Blount | TBN | 221 | 1335 | 6.0 | 10 | 53 |
| Fred Jackson | BUF | 283 | 1634 | 5.8 | 6 | 39 | Frank Gore | SFN | 274 | 1322 | 4.8 | 7 | 43 |
| Maurice Jones-Drew | JAX | 312 | 1622 | 5.2 | 18 | 34 | LeSean McCoy | PHI | 286 | 1310 | 4.6 | 8 | 62 |
| Ronnie Brown | MIA | 305 | 1593 | 5.2 | 6 | 51 | Marshawn Lynch | SEA | 280 | 1239 | 4.4 | 14 | 32 |
| Cedric Benson | CIN | 349 | 1582 | 4.5 | 7 | 26 | Felix Jones | DAL | 318 | 1234 | 3.9 | 11 | 34 |
| Ray Rice | BAL | 309 | 1563 | 5.1 | 6 | 42 | Ahmad Bradshaw | NYG | 265 | 1226 | 4.6 | 9 | 48 |
| LaDainian Tomlinson | NYJ | 263 | 1309 | 5.0 | 8 | 31 | Ryan Torain | WAS | 236 | 1166 | 4.9 | 12 | 45 |
| Darren McFadden | OAK | 248 | 1281 | 5.2 | 8 | 42 | Tim Hightower | AZN | 218 | 1130 | 5.2 | 7 | 40 |
| Mike Tolbert | SDA | 204 | 1082 | 5.3 | 16 | 36 | Brandon Jackson | GBN | 237 | 1060 | 4.5 | 4 | 25 |
| BenJarvus Green-Ellis | NEA | 208 | 1030 | 5.0 | 18 | 31 | Brandon Jacobs | NYG | 163 | 880 | 5.4 | 7 | 51 |
| Thomas Jones | KCA | 235 | 955 | 4.1 | 5 | 70 | Chris Ivory | NON | 175 | 824 | 4.7 | 7 | 25 |
| Donald Brown | IND | 189 | 873 | 4.6 | 5 | 42 | Jahvid Best | DET | 200 | 707 | 3.5 | 4 | 20 |
| Shonn Greene | NYJ | 187 | 777 | 4.2 | 10 | 23 | Mike Goodson | CAR | 149 | 692 | 4.6 | 8 | 34 |
| Joseph Addai | IND | 160 | 676 | 4.2 | 5 | 27 | Cadillac Williams | TBN | 144 | 661 | 4.6 | 7 | 33 |
| Ryan Mathews | SDA | 162 | 669 | 4.1 | 6 | 31 | Toby Gerhart | MIN | 110 | 589 | 5.4 | 3 | 21 |
| Danny Woodhead | NEA | 97 | 644 | 6.6 | 1 | 36 | Michael Vick | PHI | 101 | 578 | 5.7 | 4 | 35 |
| Michael Bush | OAK | 133 | 609 | 4.6 | 7 | 30 | Jason Snelling | ATL | 94 | 458 | 4.9 | 8 | 30 |
| Willis McGahee | BAL | 114 | 554 | 4.9 | 8 | 23 | Brian Westbrook | SFN | 111 | 452 | 4.1 | 4 | 30 |
| Ricky Williams | MIA | 100 | 494 | 4.9 | 15 | 28 | Justin Forsett | SEA | 92 | 383 | 4.2 | 3 | 32 |
| Rashad Jennings | JAX | 86 | 384 | 4.5 | 3 | 18 | Beanie Wells | AZN | 83 | 353 | 4.3 | 6 | 24 |
| Ryan Fitzpatrick | BUF | 66 | 346 | 5.2 | 2 | 22 | John Kuhn | GBN | 81 | 294 | 3.6 | 2 | 18 |
| Isaac Redman | PIT | 62 | 341 | 5.5 | 5 | 17 | DeAngelo Williams | CAR | 64 | 287 | 4.5 | 8 | 33 |
| David Garrard | JAX | 68 | 279 | 4.1 | 5 | 17 | Marion Barber III | DAL | 68 | 262 | 3.9 | 6 | 25 |
| Derrick Ward | HOU | 42 | 221 | 5.3 | 4 | 43 | Jerome Harrison | PHI | 52 | 228 | 4.4 | 3 | 39 |
| Mark Sanchez | NYJ | 44 | 174 | 4.0 | 2 | 20 | Josh Freeman | TBN | 39 | 207 | 5.3 | 0 | 33 |
| Javon Ringer | TEN | 52 | 167 | 3.2 | 3 | 20 | Aaron Rodgers | GBN | 61 | 193 | 3.2 | 2 | 18 |
| Deji Karim | JAX | 34 | 161 | 4.7 | 0 | 15 | Maurice Morris | DET | 47 | 155 | 3.3 | 1 | 18 |
| Vince Young | TEN | 39 | 149 | 3.8 | 1 | 20 | Clinton Portis | WAS | 29 | 155 | 5.3 | 1 | 27 |
| Jason Campbell | OAK | 28 | 146 | 5.2 | 2 | 20 | Pierre Thomas | NON | 38 | 152 | 4.0 | 4 | 16 |
| Brad Smith | NYJ | 18 | 141 | 7.8 | 0 | 22 | Keiland Williams | WAS | 44 | 149 | 3.4 | 3 | 17 |
| Ben Roethlisberger | PIT | 53 | 141 | 2.7 | 3 | 15 | Tashard Choice | DAL | 24 | 145 | 6.0 | 2 | 19 |
| Mewelde Moore | PIT | 30 | 129 | 4.3 | 1 | 18 | Donovan McNabb | WAS | 41 | 132 | 3.2 | 2 | 36 |
| Darren Sproles | SDA | 22 | 127 | 5.8 | 0 | 15 | Anthony Dixon | SFN | 22 | 131 | 6.0 | 1 | 19 |
| Dexter McCluster | KCA | 19 | 119 | 6.3 | 0 | 19 | Jay Cutler | CHI | 34 | 125 | 3.7 | 1 | 11 |
| Kyle Orton | DEN | 32 | 115 | 3.6 | 2 | 14 | Chester Taylor | CHI | 44 | 119 | 2.7 | 0 | 17 |
| Josh Cribbs | CLE | 26 | 107 | 4.1 | 1 | 19 | Matt Ryan | ATL | 37 | 109 | 2.9 | 6 | 12 |
| Joe McKnight | NYJ | 18 | 106 | 5.9 | 0 | 16 | Sam Bradford | STL | 62 | 99 | 1.6 | 4 | 9 |
| C.J. Spiller | BUF | 25 | 103 | 4.1 | 3 | 20 | Jon Kitna | DAL | 45 | 96 | 2.1 | 5 | 12 |
| Lousaka Polite | MIA | 48 | 97 | 2.0 | 0 | 5 | Reggie Bush | NON | 13 | 74 | 5.7 | 0 | 15 |
| Joe Flacco | BAL | 38 | 97 | 2.6 | 2 | 11 | Michael Robinson | SEA | 19 | 71 | 3.7 | 1 | 17 |
| Colt McCoy | CLE | 31 | 82 | 2.6 | 1 | 8 | Eldra Buckley | PHI | 13 | 68 | 5.2 | 1 | 13 |
| Bernard Scott | CIN | 37 | 81 | 2.2 | 1 | 13 | Kevin Smith | DET | 16 | 66 | 4.1 | 0 | 15 |
| Marcel Reece | OAK | 18 | 75 | 4.2 | 1 | 19 | Troy Smith | SFN | 10 | 54 | 5.4 | 1 | 16 |
| Steve Slaton | HOU | 15 | 72 | 4.8 | 0 | 15 | Leon Washington | SEA | 15 | 52 | 3.5 | 0 | 15 |
| Lee Evans | BUF | 13 | 70 | 5.4 | 1 | 71 | Derek Anderson | AZN | 23 | 51 | 2.2 | 1 | 7 |
| Trent Edwards | JAX | 14 | 65 | 4.6 | 1 | 10 | Alex D. Smith | SFN | 32 | 50 | 1.6 | 0 | 12 |
| Le'Ron McClain | BAL | 24 | 63 | 2.6 | 1 | 16 | Matt Hasselbeck | SEA | 29 | 48 | 1.7 | 4 | 12 |
| Tim Tebow | DEN | 10 | 58 | 5.8 | 0 | 13 | Drew Stanton | DET | 6 | 48 | 8.0 | 1 | 20 |
| Mike Bell | CLE | 25 | 39 | 1.6 | 4 | 8 | Percy Harvin | MIN | 10 | 45 | 4.5 | 0 | 15 |
| Chad Henne | MIA | 26 | 36 | 1.4 | 1 | 10 | Danny Ware | NYG | 10 | 44 | 4.4 | 0 | 14 |
| Carson Palmer | CIN | 37 | 34 | 0.9 | 2 | 9 | Tony Romo | DAL | 16 | 44 | 2.8 | 0 | 12 |
| Matt Schaub | HOU | 33 | 33 | 1.0 | 6 | 8 | LaRod Stephens-Howlin | AZN | 15 | 44 | 2.9 | 0 | 6 |
| Matt Cassel | KCA | 16 | 31 | 1.9 | 1 | 9 | Jerome Felton | DET | 15 | 37 | 2.5 | 0 | 9 |
| Bruce Gradkowski | OAK | 5 | 26 | 5.2 | 0 | 12 | Eli Manning | NYG | 32 | 35 | 1.1 | 2 | 16 |
| Jackie Battle | KCA | 11 | 24 | 2.2 | 0 | 6 | Shaun Hill | DET | 15 | 25 | 1.7 | 2 | 9 |
| Tyler Thigpen | MIA | 5 | 24 | 4.8 | 0 | 12 | Chris Redman | ATL | 6 | 20 | 3.3 | 0 | 5 |
| Patrick Cobbs | MIA | 13 | 20 | 1.5 | 0 | 5 | Matthew Stafford | DET | 7 | 20 | 2.9 | 0 | 8 |
| Jacob Hester | SDA | 9 | 12 | 1.3 | 0 | 6 | Kenneth Darby | STL | 12 | 18 | 1.5 | 8 | 5 |
| Rock Cartwright | OAK | 3 | 11 | 3.7 | 0 | 10 | Chris Gronkowski | DAL | 8 | 17 | 2.1 | 0 | 6 |
| Brian Leonard | CIN | 5 | 8 | 1.6 | 0 | 7 | Larry Fitzgerald | AZN | 2 | 17 | 8.5 | 0 | 18 |
| Quinton Ganther | BUF | 5 | 8 | 1.6 | 0 | 4 | Earnest Graham | TBN | 11 | 16 | 1.5 | 2 | 8 |
| Corey McIntyre | BUF | 10 | 7 | 0.7 | 0 | 5 | Garrett Wolfe | CHI | 5 | 15 | 3.0 | 0 | 7 |
| Correll Buckhalter | DEN | 3 | 7 | 2.3 | 1 | 7 | John Skelton | AZN | 5 | 14 | 2.8 | 0 | 6 |
| Tony Richardson | NYJ | 4 | 7 | 1.8 | 0 | 5 | Brett Favre | MIN | 24 | 14 | 0.6 | 2 | 7 |
| Peyton Manning | IND | 22 | 7 | 0.3 | 3 | 6 | Jimmy Clausen | CAR | 34 | 14 | 0.4 | 1 | 8 |
| Greg Jones | JAX | 3 | 7 | 2.3 | 0 | 5 | Joe Webb | MIN | 5 | 12 | 2.4 | 0 | 6 |
| Todd Bouman | JAX | 2 | 6 | 3.0 | 0 | 5 | Mike Karney | STL | 2 | 10 | 5.0 | 0 | 5 |
| Lance Ball | DEN | 3 | 6 | 2.0 | 0 | 5 | Gartrell Johnson | ATL | 2 | 9 | 4.5 | 0 | 15 |
| Ahmard Hall | TEN | 1 | 5 | 5.0 | 0 | 5 | Heath Evans | NON | 2 | 8 | 4.0 | 1 | 5 |
| Jake Delhomme | CLE | 3 | 4 | 1.3 | 0 | 5 | Kevin Kolb | PHI | 5 | 7 | 1.4 | 0 | 7 |
| Billy Volek | SDA | 2 | 4 | 2.0 | 0 | 5 | Ovie Mughelli | ATL | 5 | 7 | 1.4 | 2 | 6 |
| Brodie Croyle | KCA | 2 | 4 | 2.0 | 0 | 5 | Keith Toston | STL | 2 | 6 | 3.0 | 0 | 6 |
| Tim Castille | KCA | 3 | 3 | 1.0 | 0 | 5 | Rex Grossman | WAS | 2 | 5 | 2.5 | 1 | 4 |
| Javarris James | IND | 3 | 3 | 1.0 | 1 | 3 | Moran Norris | SFN | 1 | 1 | 1.0 | 1 | 1 |
| Tom Brady | NEA | 47 | 3 | 0.1 | 6 | 6 | James Starks | GBN | 4 | 1 | 0.3 | 1 | 1 |
| Fred Taylor | NEA | 1 | 3 | 3.0 | 0 | 3 | Chris Kluwe | MIN | 1 | 0 | 0.0 | 0 | 0 |
| Lawrence Vickers | CLE | 1 | 2 | 2.0 | 1 | 2 | Charlie Whitehurst | SEA | 2 | -2 | -1.0 | 0 | -1 |
| David Johnson | PIT | 6 | 1 | 0.2 | 0 | 5 | Todd Collins | CHI | 2 | -2 | -1.0 | 0 | -1 |
| Kerry Collins | TEN | 19 | 1 | 0.1 | 1 | 5 | Matt Moore | CAR | 2 | -3 | -1.5 | 0 | -1 |
| Sammy Morris | NEA | 1 | 1 | 1.0 | 0 | 1 | Brandon Gibson | STL | 1 | -4 | -4.0 | 0 | -4 |
| Jacoby Ford | OAK | 1 | 0 | 0.0 | 0 | 0 | Steve Breaston | AZN | 1 | -5 | -5.0 | 0 | -5 |
| Davone Bess | MIA | 1 | 0 | 0.0 | 0 | 0 | Drew Brees | NON | 15 | -6 | -0.4 | 1 | 6 |
| Seneca Wallace | CLE | 5 | 0 | 0.0 | 0 | 4 | Steve L. Smith | CAR | 2 | -6 | -3.0 | 0 | -2 |
| Mike Hart | IND | 1 | -1 | -1.0 | 0 | -1 | |||||||
| Brian Brohm | BUF | 1 | -1 | -1.0 | 0 | -1 | |||||||
| John Conner | NYJ | 1 | -1 | -1.0 | 0 | -1 | |||||||
| Charlie Batch | PIT | 2 | -2 | -1.0 | 0 | -1 | |||||||
| Brandon Lloyd | DEN | 1 | -2 | -2.0 | 0 | -2 | |||||||
| Dennis Dixon | PIT | 4 | -2 | -0.5 | 0 | 1 | |||||||
| Reggie Wayne | IND | 1 | -2 | -2.0 | 0 | -2 | |||||||
| Terrell Owens | CIN | 1 | -2 | -2.0 | 0 | -2 | |||||||
| Donald Jones | BUF | 1 | -3 | -3.0 | 0 | -3 | |||||||
| Dwayne Bowe | KCA | 1 | -3 | -3.0 | 0 | -3 | |||||||
| Braylon Edwards | NYJ | 1 | -4 | -4.0 | 0 | -4 | |||||||
| Roscoe Parrish | BUF | 1 | -5 | -5.0 | 0 | -5 | |||||||
| Pierre Garcon | IND | 2 | -6 | -3.0 | 0 | -2 | |||||||
| Philip Rivers | SDA | 20 | -7 | -0.4 | 1 | 6 | |||||||
| Mike Wallace | PIT | 4 | -9 | -2.3 | 0 | 0 | |||||||
| David Nelson | BUF | 2 | -12 | -6.0 | 0 | -5 |