| PASSING | TM | ATT | COM | PCT | YDS | YPA | TD | TD % | INT | INT % | RAT | PASSING | TM | ATT | COM | PCT | YDS | YPA | TD | TD % | INT | INT % | RAT |
| Philip Rivers | SDA | 514 | 321 | 62.5% | 4349 | 8.5 | 30 | 5.8% | 14 | 2.7% | 97.5 | Alex D. Smith | SFN | 471 | 285 | 60.5% | 3428 | 7.3 | 33 | 7.0% | 11 | 2.3% | 96.5 |
| Matt Cassel | KCA | 461 | 258 | 56.0% | 3260 | 7.1 | 34 | 7.4% | 7 | 1.5% | 96.4 | Michael Vick | PHI | 385 | 218 | 56.6% | 2903 | 7.5 | 20 | 5.2% | 4 | 1.0% | 93.7 |
| Matt Schaub | HOU | 552 | 313 | 56.7% | 3913 | 7.1 | 36 | 6.5% | 8 | 1.4% | 94.6 | Aaron Rodgers | GBN | 674 | 395 | 58.6% | 4596 | 6.8 | 35 | 5.2% | 17 | 2.5% | 86.1 |
| Tom Brady | NEA | 681 | 411 | 60.4% | 4834 | 7.1 | 32 | 4.7% | 14 | 2.1% | 89.1 | Sam Bradford | STL | 604 | 368 | 60.9% | 4284 | 7.1 | 21 | 3.5% | 15 | 2.5% | 83.7 |
| Kyle Orton | DEN | 491 | 268 | 54.6% | 3349 | 6.8 | 31 | 6.3% | 11 | 2.2% | 87.7 | Josh Freeman | TBN | 551 | 307 | 55.7% | 3707 | 6.7 | 26 | 4.7% | 12 | 2.2% | 83.2 |
| Ryan Fitzpatrick | BUF | 468 | 256 | 54.7% | 3252 | 6.9 | 27 | 5.8% | 11 | 2.4% | 86.1 | Matt Hasselbeck | SEA | 600 | 371 | 61.8% | 4161 | 6.9 | 24 | 4.0% | 19 | 3.2% | 82.6 |
| Ben Roethlisberger | PIT | 541 | 301 | 55.6% | 3675 | 6.8 | 30 | 5.5% | 12 | 2.2% | 86.0 | Tony Romo | DAL | 245 | 160 | 65.3% | 1709 | 7.0 | 8 | 3.3% | 9 | 3.7% | 81.1 |
| Peyton Manning | IND | 674 | 394 | 58.5% | 4743 | 7.0 | 38 | 5.6% | 21 | 3.1% | 85.9 | Matt Ryan | ATL | 525 | 293 | 55.8% | 3151 | 6.0 | 24 | 4.6% | 10 | 1.9% | 80.9 |
| Carson Palmer | CIN | 561 | 331 | 59.0% | 3734 | 6.7 | 28 | 5.0% | 17 | 3.0% | 83.0 | Donovan McNabb | WAS | 463 | 244 | 52.7% | 3056 | 6.6 | 21 | 4.5% | 10 | 2.2% | 79.6 |
| David Garrard | JAX | 372 | 217 | 58.3% | 2474 | 6.7 | 16 | 4.3% | 10 | 2.7% | 81.5 | Eli Manning | NYG | 562 | 305 | 54.3% | 3836 | 6.8 | 34 | 6.0% | 25 | 4.4% | 77.4 |
| Joe Flacco | BAL | 537 | 288 | 53.6% | 3348 | 6.2 | 25 | 4.7% | 11 | 2.0% | 79.7 | Drew Brees | NON | 753 | 425 | 56.4% | 5057 | 6.7 | 38 | 5.0% | 31 | 4.1% | 76.8 |
| Chad Henne | MIA | 507 | 283 | 55.8% | 3082 | 6.1 | 19 | 3.7% | 11 | 2.2% | 77.4 | Jon Kitna | DAL | 321 | 198 | 61.7% | 2073 | 6.5 | 11 | 3.4% | 12 | 3.7% | 76.2 |
| Jason Campbell | OAK | 483 | 272 | 56.3% | 2827 | 5.9 | 14 | 2.9% | 7 | 1.4% | 77.0 | Brett Favre | MIN | 459 | 260 | 56.6% | 2949 | 6.4 | 21 | 4.6% | 18 | 3.9% | 75.0 |
| Colt McCoy | CLE | 359 | 197 | 54.9% | 1976 | 5.5 | 16 | 4.5% | 9 | 2.5% | 75.2 | Jimmy Clausen | CAR | 350 | 177 | 50.6% | 2033 | 5.8 | 11 | 3.1% | 8 | 2.3% | 69.4 |
| Kerry Collins | TEN | 278 | 138 | 49.6% | 1965 | 7.1 | 14 | 5.0% | 10 | 3.6% | 74.7 | Shaun Hill | DET | 529 | 271 | 51.2% | 2842 | 5.4 | 13 | 2.5% | 13 | 2.5% | 65.1 |
| Mark Sanchez | NYJ | 480 | 213 | 44.4% | 2687 | 5.6 | 16 | 3.3% | 11 | 2.3% | 63.9 | Derek Anderson | AZN | 401 | 190 | 47.4% | 2137 | 5.3 | 15 | 3.7% | 11 | 2.7% | 64.8 |
| Vince Young | TEN | 198 | 124 | 62.6% | 1849 | 9.3 | 20 | 10.1% | 3 | 1.5% | 120.5 | Jay Cutler | CHI | 536 | 279 | 52.1% | 3189 | 5.9 | 20 | 3.7% | 24 | 4.5% | 64.0 |
| Charlie Batch | PIT | 3 | 2 | 66.7% | 39 | 13.0 | 0 | 0.0% | 0 | 0.0% | 109.7 | Charlie Whitehurst | SEA | 39 | 26 | 66.7% | 304 | 7.8 | 2 | 5.1% | 0 | 0.0% | 107.2 |
| Tim Tebow | DEN | 29 | 17 | 58.6% | 275 | 9.5 | 3 | 10.3% | 2 | 6.9% | 96.2 | Kevin Kolb | PHI | 80 | 47 | 58.8% | 650 | 8.1 | 7 | 8.8% | 2 | 2.5% | 103.6 |
| Brian Brohm | BUF | 1 | 1 | 100.0% | 4 | 4.0 | 0 | 0.0% | 0 | 0.0% | 83.3 | Rex Grossman | WAS | 108 | 70 | 64.8% | 824 | 7.6 | 6 | 5.6% | 1 | 0.9% | 102.5 |
| Todd Bouman | JAX | 33 | 17 | 51.5% | 201 | 6.1 | 1 | 3.0% | 0 | 0.0% | 80.5 | Matthew Stafford | DET | 128 | 79 | 61.7% | 828 | 6.5 | 5 | 3.9% | 2 | 1.6% | 87.0 |
| Dennis Dixon | PIT | 4 | 3 | 75.0% | 15 | 3.8 | 0 | 0.0% | 0 | 0.0% | 80.2 | Troy Smith | SFN | 58 | 33 | 56.9% | 411 | 7.1 | 3 | 5.2% | 2 | 3.4% | 81.9 |
| Seneca Wallace | CLE | 92 | 51 | 55.4% | 531 | 5.8 | 4 | 4.3% | 3 | 3.3% | 73.2 | Ben Graham | AZN | 2 | 1 | 50.0% | 17 | 8.5 | 0 | 0.0% | 0 | 0.0% | 79.2 |
| Trent Edwards | JAX | 109 | 57 | 52.3% | 519 | 4.8 | 2 | 1.8% | 3 | 2.8% | 60.1 | Drew Stanton | DET | 10 | 5 | 50.0% | 53 | 5.3 | 0 | 0.0% | 0 | 0.0% | 65.8 |
| Bruce Gradkowski | OAK | 66 | 29 | 43.9% | 421 | 6.4 | 1 | 1.5% | 2 | 3.0% | 57.7 | Matt Moore | CAR | 47 | 24 | 51.1% | 344 | 7.3 | 1 | 2.1% | 2 | 4.3% | 64.5 |
| Billy Volek | SDA | 2 | 0 | 0.0% | 0 | 0.0 | 0 | 0.0% | 0 | 0.0% | 39.6 | John Skelton | AZN | 60 | 28 | 46.7% | 305 | 5.1 | 1 | 1.7% | 1 | 1.7% | 60.8 |
| Jake Delhomme | CLE | 67 | 21 | 31.3% | 294 | 4.4 | 0 | 0.0% | 4 | 6.0% | 21.6 | Max Hall | AZN | 34 | 21 | 61.8% | 238 | 7.0 | 0 | 0.0% | 2 | 5.9% | 58.2 |
| Joe Webb | MIN | 58 | 28 | 48.3% | 282 | 4.9 | 1 | 1.7% | 3 | 5.2% | 46.8 | ||||||||||||
| Todd Collins | CHI | 1 | 0 | 0.0% | 0 | 0.0 | 0 | 0.0% | 0 | 0.0% | 39.6 | ||||||||||||
| Josh Johnson | TBN | 3 | 1 | 33.3% | 7 | 2.3 | 0 | 0.0% | 1 | 33.3% | 2.8 |